FDA Approved — April 2026

The GLP-1 weight loss pill with no food or water restrictions

Foundayo™ (orforglipron, pronounced "fown-DAY-oh") is Eli Lilly's new once-daily pill. Take it any time of day, with or without food. Now available through LillyDirect.

Get Started on LillyDirect See Pricing
12.4%
Avg. body weight lost
$25/mo
As low as with insurance
1x
Daily pill, any time
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Why Foundayo is different

  • ✓ Take any time of day
  • ✓ No fasting or water restrictions
  • ✓ Small, once-daily oral tablet
  • ✓ No injections needed
  • ✓ Available now via LillyDirect
✅ FDA Approved
💕 From $25/mo
About the Medication

What is Foundayo?

Foundayo (orforglipron, pronounced "fown-DAY-oh") is an FDA-approved, non-peptide, oral GLP-1 receptor agonist developed by Eli Lilly for chronic weight management in adults. Available as a Pen or Vial.

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Oral GLP-1 Medication

A once-daily pill—not an injection. Foundayo is a small-molecule GLP-1 receptor agonist, distinct from peptide-based alternatives like semaglutide.

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Take It Any Time

Unlike other GLP-1 pills, Foundayo has no food or water restrictions and can be taken at any time of day—morning, afternoon, or evening.

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Who It's For

Approved for adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related medical condition, alongside diet and exercise.

Getting Started

How to get Foundayo

From consultation to your doorstep, here's how the process works through LillyDirect.

1

Visit LillyDirect

Go to LillyDirect.com and start your weight management consultation online.

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2

Clinician Review

A licensed healthcare provider reviews your information and determines if Foundayo is right for you.

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3

Get Your Prescription

If prescribed, your Foundayo prescription is sent directly to a pharmacy for fulfillment.

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4

Delivered to You

Receive Foundayo at your door. Home delivery via LillyDirect begins shipping April 6, 2026.

Clinical Evidence

Proven results from the ATTAIN-1 trial

A 72-week, randomized, double-blind, placebo-controlled study with 3,127 participants.

Foundayo (highest dose) — avg. weight loss
27.3 lbs (12.4%)
Foundayo (all doses) — avg. weight loss
25 lbs (11.1%)
Placebo — avg. weight loss
2.2 lbs

Source: ATTAIN-1 Phase 3 clinical trial (72 weeks). Individual results may vary. Foundayo is taken alongside reduced-calorie diet and increased physical activity.

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Significant weight reduction

Participants on the highest dose lost an average of 27.3 pounds over 72 weeks, compared to just 2.2 pounds with placebo.

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Cardiovascular risk markers improved

The trial showed additional benefits including reductions in cardiovascular risk markers among participants taking Foundayo.

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Large-scale, rigorous trial

ATTAIN-1 enrolled 3,127 adults in a randomized, double-blind, placebo-controlled design—one of the largest oral GLP-1 trials conducted.

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Ongoing research

Orforglipron is also being studied for type 2 diabetes, sleep apnea, arthritis, hypertension, and other conditions.

Pricing

Affordable access to Foundayo

Multiple pathways to make Foundayo accessible, whether you have commercial insurance, Medicare, or are paying out of pocket.

With Insurance
$25
per month — as low as

Eligible patients with commercial insurance can use the Foundayo Savings Card to pay as little as $25/month. Savings of up to $100/month ($1,000/year max). Card expires 12/31/2026.

Self-Pay
$149
per month — starting at

No insurance? Self-pay pricing ranges from $149/month to $299/month depending on dose. No insurance needed. See full pricing by dose →

Medicare Part D
$50
per month — starting July 2026

Eligible Medicare Part D beneficiaries may be able to access Foundayo for $50/month beginning as soon as July 1, 2026.

Get Started

Ready to get Foundayo?

Foundayo is currently available exclusively through LillyDirect, Eli Lilly's direct-to-patient platform.

Start your journey on LillyDirect

LillyDirect connects you with independent healthcare providers who can evaluate whether Foundayo is right for you. Prescriptions are being accepted now, with home delivery beginning April 6.

Visit LillyDirect.com
🔒 Official Eli Lilly Patient Platform
More Ways to Access

Telehealth providers

Soon, you'll be able to get Foundayo through additional telehealth platforms. We're tracking availability as it expands.

🔔 Coming Soon

Telehealth access is on the way

We're tracking which telehealth providers will offer Foundayo prescriptions. Check back soon for updates as availability expands beyond LillyDirect.

Common Questions

Frequently asked questions

Everything you need to know about Foundayo, from dosing to side effects.

Foundayo (orforglipron) is an oral GLP-1 receptor agonist. It works by mimicking the GLP-1 hormone, which helps regulate appetite and food intake. This leads to reduced hunger and caloric intake, supporting weight loss when combined with a reduced-calorie diet and increased physical activity.
Foundayo is an oral pill (not an injection), can be taken at any time of day, and has no food or water restrictions. Wegovy and Ozempic are injectable semaglutide medications. Foundayo is also a non-peptide small molecule, which is a different drug class than peptide-based GLP-1s.
You can take Foundayo at any time of day—morning, afternoon, or evening. There are no fasting requirements and no restrictions on food or water intake before or after taking the pill. Swallow the tablet whole; do not break, crush, or chew it.
In the ATTAIN-1 clinical trial, participants on the highest dose of Foundayo lost an average of 12.4% of their body weight (about 27.3 pounds) over 72 weeks. Individual results vary based on factors including dosage, diet, exercise, and overall health.
The most common side effects include nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, swollen belly, headache, fatigue, belching, heartburn, gas, and hair loss. Side effects are generally most common during the dose-escalation period and often improve over time.
Foundayo is approved for adults with obesity (BMI of 30 or greater) or overweight (BMI of 27 or greater) who also have at least one weight-related medical condition such as high blood pressure, type 2 diabetes, or high cholesterol. It is used alongside a reduced-calorie diet and increased physical activity.
Foundayo is available in six strengths: 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, and 17.2 mg. Your healthcare provider will start you on a lower dose and gradually increase it to reduce the chance of gastrointestinal side effects.
Oral birth control pills may be less effective when taken with Foundayo. Alternative or backup contraception is recommended for 30 days after starting Foundayo and for 30 days after each dose increase. Talk to your healthcare provider about your options.
If you miss a dose, take it as soon as you remember on the same day. If 7 or more days have passed since your last dose, contact your healthcare provider before restarting—they may need to adjust your dosing schedule.
Safety Information

Important Safety Information

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WARNING: THYROID C-CELL TUMORS. In animal studies, GLP-1 receptor agonists caused thyroid tumors, including thyroid cancer. It is not known if Foundayo causes thyroid tumors or cancer in people. Do not use Foundayo if you or any of your family members have had medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your healthcare provider if you notice a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Do not use Foundayo if you:

  • Have a personal or family history of medullary thyroid carcinoma (MTC)
  • Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • Have had a serious allergic reaction to orforglipron or any ingredients in Foundayo

Serious side effects may include:

  • Inflammation of the pancreas (pancreatitis)
  • Gallbladder problems, including gallstones
  • Low blood sugar (hypoglycemia), especially if taken with other diabetes medications
  • Kidney problems, including kidney failure
  • Serious allergic reactions
  • Changes in vision in patients with type 2 diabetes
  • Severe stomach problems including gastroparesis

Most common side effects:

Nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, swollen belly, headache, fatigue, belching, heartburn, gas, and hair loss.

Before taking Foundayo, tell your healthcare provider about all of your medical conditions, including if you:

  • Have or have had problems with your pancreas or kidneys
  • Have a history of diabetic retinopathy
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Take other GLP-1 receptor agonist medications or diabetes medications
  • Take oral contraceptives (birth control pills may be less effective)

Pregnancy warning:

Foundayo may cause harm to an unborn baby. Stop taking Foundayo at least 2 months before a planned pregnancy. If you become pregnant while taking Foundayo, stop taking it and call your healthcare provider immediately.

Surgery warning:

Tell your healthcare provider if you are planning to have surgery. Foundayo may increase the risk of food or liquid getting into your lungs during anesthesia (aspiration). Your provider may ask you to stop Foundayo before a scheduled surgery.

This is not a complete list of side effects and safety information. Please see the full Prescribing Information, including Boxed Warning, and discuss with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.